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1-Methylpsilocin

Catalog #: 3017
1 Citation Datasheet / COA / SDS
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3017/10
3017/50
1-Methylpsilocin | CAS No. 1465-16-3 | 5-HT2C Receptor Agonists
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Description: Potent and selective 5-HT2C agonist

Chemical Name: 3-[2-(Dimethylamino)ethyl]-1-methylindol-4-ol

Purity: ≥99%

Product Details
Citations (1)
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Biological Activity

1-Methylpsilocin is a potent and selective 5-HT2C agonist (IC50 values are 12 and 633 nM for 5-HT2C and 5-HT2A receptors respectively). Displays high affinity for the 5-HT2B receptor (Ki = 38 nM) but acts as an inverse agonist. Active in vivo; inhibits scratching in a mouse model of OCD.

Technical Data

M.Wt:
218.29
Formula:
C13H18N2O
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
1465-16-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. SAR of psilocybin analogs: discovery of a selective 5-HT2C agonist.
    Sard et al.
    Bioorg.Med.Chem.Letts., 2005;15:4559

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Citation for 1-Methylpsilocin

The citations listed below are publications that use Tocris products. Selected citations for 1-Methylpsilocin include:

1 Citation: Showing 1 - 1

  1. Differential contributions of serotonin receptors to the behavioral effects of indoleamine hallucinogens in mice.
    Authors: Halberstadt Et al.
    J.Psychopharmacol.  2011;25:1548

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