10058-F4
Chemical Name: 5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone
Purity: ≥99%
Biological Activity
10058-F4 is a cell permeable c-Myc-Max dimerization inhibitor. Inhibits proliferation, induces apoptosis and arrests cells in G0/G1 in rat1a-c-Myc cells. Also reduces tumor growth in vivo. In lymphoma cells, 10058-F4 decreases glucose uptake and expression of glycolysis-associated genes and reduces cell viability.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Low molecular weight inhibitors of Myc-Max interaction and function.
Yin et al.
Oncogene, 2003;22:6151 -
Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc-Max disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice.
Guo et al.
Cancer Chemother.Pharmacol., 2009;63:615 -
A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia.
Huang et al.
Exp.Hematol., 2006;34:1480
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