2-Iodomelatonin

Catalog #: 0737
5 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
0737/10
0737/50

2-Iodomelatonin | CAS No. 93515-00-5 | Melatonin (MT) Receptor Agonists

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Description: High affinity melatonin agonist

Chemical Name: N-[2-(2-Iodo-5-methoxyindol-3-yl)ethyl]acetamide

Purity: ≥98%

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Product Details

Citations (5)

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

2-Iodomelatonin is a potent melatonin agonist (pK_i values are 10.55 and 9.87 at human recombinant MT₁ and MT₂ receptors respectively). 2-[¹²⁵I]-iodomelatonin has been used to identify, characterize and localize melatonin binding sites in the brain and peripheral tissues.

Technical Data

M.Wt:

358.18

Formula:

C₁₃H₁₅IN₂O₂

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

93515-00-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Pharmacological characterization of human recombinant melatonin mt₁ and MT₂ receptors.
Browning et al.
Br.J.Pharmacol., 2000;129:877
Use of 2-[¹²⁵l]-iodomelatonin to characterize melatonin sites in chicken retina.
Dubocovich and Takahashi
Proc.Natl.Acad.Sci.U.S.A., 1987;84:3916
Quantitative pharmacological analysis of 2-[¹²⁵l]-iodomelatonin binding sites in discrete areas of the chicken brain.
Suiciak et al.
J.Neurosci., 1991;11:2855

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Citations for 2-Iodomelatonin

The citations listed below are publications that use Tocris products. Selected citations for 2-Iodomelatonin include:

5 Citations: Showing 1 - 5

A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression.
Authors: Akoume Et al.
Sci Rep 2019;9:10074
Structural basis of ligand recognition at the human MT1 melatonin receptor
Authors: Stauch Et al.
Nature 2019;569:284
Homeostatic Plasticity Mediated by Rod-Cone Gap Junction Coupling in Retinal Degenerative Dystrophic RCS Rats.
Authors: Hou Et al.
Front Cell Neurosci 2017;11:98
Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2.
Authors: Calamini Et al.
Biochem J 2008;413:81
Identification of the melatonin-binding site MT3 as the quinone reductase 2.
Authors: Nosjean Et al.
J Biol Chem 2000;275:31311

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