2-Palmitoylglycerol
Discontinued Product
Chemical Name: 2-Hydroxy-1-(hydroxymethyl)ethyl hexadecanoic acid ester
Biological Activity
2-Palmitoylglycerol is a endogenous fatty acid glycerol ester that enhances activity of 2-arachidonylglycerol (Cat. No. 1298). Does not bind to CB1 or CB2 cannabinoid receptors, but potentiates the apparent binding of 2-AG and increases its ability to inhibit adenylyl cyclase. Enhances in vivo cannabinoid effects of 2-AG following combined administration with 2-linoleoylglycerol.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonyl-glycerol cannabinoid activity.
Ben-Shabat et al.
Eur.J.Pharmacol., 1998;353:23 -
2-Arachidonylglycerol, an endogenous cannabinoid, inhibits tumor necrosis factor-α production in murine macrophages, and in mice.
Gallily et al.
Eur.J.Pharmacol., 2000;406:R5 -
Endocannabinoids and related fatty acid derivatives in pain modulation.
Walker et al.
Chem.Phys.Lipids, 2002;121:159
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