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3-Bromopyruvate

Catalog #: 7512 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7512/100
3-Bromopyruvate | CAS No. 1113-59-3 | Monocarboxylate Transporter Inhibitors
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Description: MCT1 inhibitor; also inhibits hexokinase II

Chemical Name: 3-Bromo-2-oxopropanoic acid

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Biological Activity

3-Bromopyruvate is a monocarboxylate transporter (MCT1) inhibitor (IC50 = 14.7 μM, 24.2 μM and 28.6 μM in SiHa, UM-UC-3, and HCT-116 human cancer cell lines, respectively). 3-Bromopyruvate shows antitumor activity in vitro and in vivo. 3-Bromopyruvate is also an inhibitor of hexokinase II, and decreases apoptosis in dopaminergic neurons in Parkinson's disease models in vitro and in vivo.

Technical Data

M.Wt:
166.96
Formula:
C3H3BrO3
Solubility:
Soluble to 100 mM in water
Storage:
Store at -20°C
CAS No:
1113-59-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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