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7-Chlorokynurenic acid

Catalog #: 0237
6 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
0237/10
0237/50
7-Chlorokynurenic acid | CAS No. 18000-24-3 | Glutamate (EAAT) Transporter Inhibitors
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Description: Potent competitive inhibitor of L-glutamate uptake

Chemical Name: 7-Chloro-4-hydroxyquinoline-2-carboxylic acid

Purity: ≥98%

Product Details
Citations (6)
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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

7-Chlorokynurenic acid is an NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles.

Sodium Salt also available.

Technical Data

M.Wt:
223.62
Formula:
C10H6ClNO3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
18000-24-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. Olanzapine: preclinical and clinical profiles of a novel antipsychotic agent.
    Tollefson and Taylor
    CNS Drug Reviews, 2000;6:303
  2. Behavioral and neurochemical actions of the strychnine-insensitive glycine receptor antagonist, 7-chlorokynurenate, in rats.
    Kretschmer et al.
    Eur.J.Pharmacol., 1995;280:37
  3. Substituted quinolines as inhibitors of L-glutamate transport into synaptic vesicles.
    Bartlett et al.
    Neuropharmacology, 1998;37:839
  4. 7-Chlorokynurenic acid is a selective antagonist of the glycine modulatory site of the NMDA receptor complex.
    Kemp et al.
    Proc.Natl.Acad.Sci.U.S.A., 1988;85:6547
  5. Characterization of [3H]-glycine binding to a modulatory site within the NMDA receptor complex from rat brain.
    Donald et al.
    Br.J.Pharmacol., 1988;95:892P

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Citations for 7-Chlorokynurenic acid

The citations listed below are publications that use Tocris products. Selected citations for 7-Chlorokynurenic acid include:

6 Citations: Showing 1 - 6

  1. NMDA receptor signaling in oligodendrocyte progenitors is not required for oligodendrogenesis and myelination.
    Authors: Biase Et al.
    Proc Natl Acad Sci U S A  2011;31:12650
  2. White matter vulnerability to ischemic injury increases with age because of enhanced excitotoxicity.
    Authors: Baltan Et al.
    J Neurosci  2008;28:1479
  3. Differential compartmentalization and distinct functions of GABAB receptor variants.
    Authors: Vigot Et al.
    Neuron  2006;50:589
  4. Vasoconstrictive neurovascular coupling during focal ischemic depolarizations.
    Authors: Shin Et al.
    J Cereb Blood Flow Metab  2006;26:1018
  5. Presynaptic N-MthD.-aspartate receptors at the parallel fiber-Purkinje cell synapse.
    Authors: Casado Et al.
    Proc Natl Acad Sci U S A  2000;97:11593
  6. Inhibition of [3H]-(+)-MK 801 binding to rat brain sections by CPP and 7-chlorokynurenic acid: an autoradiographic analysis.
    Authors: Tacconi Et al.
    Br J Pharmacol  1993;108:577

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