8-pCPT-2-O-Me-cAMP-AM

Biological Activity

This product is a mixture of axial and equatorial isomers. Both isomers give 8CPT-2Me-cAMP after esterase cleavage.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Background References

1. Glucagon stimulates hepatic FGF21 secretion through a PKA- and EPAC-dependent posttranscriptional mechanism.
   Cyphert H, Alonge K, Ippagunta S, Hillgartner F
   PLoS ONE, 2014;9(4):e94996.
2. Glucagon and Insulin Cooperatively Stimulate Fibroblast Growth Factor 21 Gene Transcription by Increasing the Expression of Activating Transcription Factor 4
   KM Alonge, GP Meares, FB Hillgartne
   J. Biol. Chem, 2017;0(0):.
3. Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration.
   Watson R, Buck J, Levin L, Winger R, Wang J, Arase H, Muller W
   J Exp Med, 2015;212(7):1021-41.
4. Enhanced Rap1 activation and Ins secretagogue properties of an acetoxymethyl ester of an Epac-selective cyclic AMP analog in rat INS-1 cells: studies with 8-pCPT-2'-O-Me-cAMP-AM.
   Chepurny et al.
   J.Biol.Chem., 2009;284:10728
5. Isoform-specific antagonists of exchange proteins directly activated by cAMP.
   Tsalkova et al.
   Proc.Natl.Acad.Sci.USA., 2012;109:18613
6. 8-pCPT-2'-O-Me-cAMP-AM: an improved Epac-selective cAMP analogue.
   Vliem et al.
   Chembiochem., 2008;9:2052
7. A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion.
   Almahariq et al.
   Mol.Pharmacol., 2013;83:122

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