A 205804
Chemical Name: 4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide
Purity: ≥98%
Biological Activity
A 205804 is a selective inhibitor of E-selectin and ICAM-1 expression (IC50 values are 20, 25 and > 1000 nM for TNF-α-induced E-selectin, ICAM-1 and VCAM-1 expression respectively). Effective inhibitor of cell-cell adhesion in an in vitro flow experiment.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Discovery of inhibitors of cell adhesion molecule expression in human endothelial cells. 1. Selective inhibition of ICAM-1 and E-selectin expression.
Stewart et al.
J.Med.Chem., 2001;44:988 -
Selective inhibition of ICAM-1 and E-selectin expression in human endothelial cells. 2. Aryl modifications of 4-(aryloxy)thieno[2,3-c]pyridines with fine-tuning at C-2 carbamides.
Zhu et al.
J.Med.Chem., 2001;44:3469 -
Synthesis and mode of action of 125I- and 3H-labeled thieno[2,3-c]pyridine antagonists of cell adhesion molecule expression.
Zhu et al.
J.Org.Chem., 2002;67:943
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Citation for A 205804
The citations listed below are publications that use Tocris products. Selected citations for A 205804 include:
1 Citation: Showing 1 - 1
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ICAM-1 regulates the survival of influenza virus in lung epithelial cells during the early stages of infection.
Authors: Othumpangat Et al.
Virology 2016;487:85
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