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A 410099.1 amide-PEG5-amine

Catalog #: 7221 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7221/25
A 410099.1 amide-PEG5-amine | CAS No. 2446474-11-7 | Degrader Building Blocks
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Description: IAP ligand with PEG linker and terminal amine for onward chemistry

Chemical Name: tert-Butyl ((S)-1-(((S)-2-((2S,4S)-4-(17-amino-3,6,9,12,15-pentaoxaheptadecanamido)-2-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)amino)-1-oxopropan-2-yl)(methyl)carbamate

Purity: ≥95%

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Biological Activity

A 410099.1 amide-PEG5-amine is a functionalized IAP ligand for PROTAC® research and development; incorporates an IAP ligand plus an amide-PEG5 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data

M.Wt:
861.09
Formula:
C44H72N6O11
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
2446474-11-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. PROTAC-mediated degradation of Bruton's tyrosine kinase is inhibited by covalent binding.
    Tinworth et al.
    ACS Chem.Biol., 2019;14:342

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