Home / P2X Receptor Antagonists / A 804598

A 804598

Catalog #: 4473
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4473/10
4473/50
A 804598 | CAS No. 1125758-85-1 | P2X Receptor Antagonists
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Description: Potent and selective P2X7 antagonist

Chemical Name: N-Cyano-N"-[(1S)-1-phenylethyl]-N'-5-quinolinyl-guanidine

Purity: ≥99%

Product Details
Citations (3)
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Biological Activity

A 804598 is a potent, competitive P2X7 receptor antagonist (IC50 values are 8.9, 9.9 and 10.9 nM for mouse, rat and human P2X7 receptors respectively). Selective for P2X7 receptors (IC50 > 5-10 μM for a wide array of cell surface receptors and ion channels). Binds with high affinity (Ki app = 2.4 nM for rat P2X7 receptors).

Technical Data

M.Wt:
315.37
Formula:
C19H17N5
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
1125758-85-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for A 804598

The citations listed below are publications that use Tocris products. Selected citations for A 804598 include:

3 Citations: Showing 1 - 3

  1. Blocking of P2X7r Reduces Mitochondrial Stress Induced by Alcohol and Electronic Cigarette Exposure in Brain Microvascular Endothelial Cells.
    Authors: Yuri Et al.
    Antioxidants (Basel)  2022;11
  2. Connexin-43-dependent ATP release mediates macrophage activation during sepsis.
    Authors: Dosch Et al.
    Elife  2019;8
  3. A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90.
    Authors: Young Et al.
    Cell Commun Signal  2015;11:113

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