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ABT 639

Catalog #: 6770 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6770/10
ABT 639 | CAS No. 1235560-28-7 | Cav3.x Channel Blockers
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Description: CaV3.2 and CaV3.1 channel blocker; orally bioavailable

Chemical Name: 4-Chloro-2-fluoro-N-(2-fluorophenyl)-5-[[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl]benzenesulfonamide

Purity: ≥98%

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Biological Activity

ABT 639 is a CaV3.2 channel blocker (IC50 = 2.3 μM). Also blocks low voltage-activated (CaV3.1) currents in native rat DRG neurons (IC50 = 7.6 μM). Exhibits little or no activity at other ion channels and receptors. Displays antinociceptive effects in a mechanical hyperalgesia model in vivo. Orally bioavailable.

Technical Data

M.Wt:
455.91
Formula:
C20H20ClF2N3O3S
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1235560-28-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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