ABT 737
Chemical Name: 4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide
Purity: ≥98%
Biological Activity
ABT 737 is a high affinity Bcl-2 family inhibitor (Ki ≤ 1nM for Bcl-XL, Bcl-2 and Bcl-w). BH3 mimetic; triggers Bax/Bak-mediated apoptosis. Exhibits cytotoxicity in lymphoma cell lines overexpressing bcl-2 (EC50 < 1 μM) and multiple myeloma cells (IC50 = 5-15 μM). Induces apoptosis in patient-derived CLL cells. Promotes regression of SCLC tumors in a mouse xenograft model. Synergizes with certain other anticancer agents.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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An inhibitor of Bcl-2 family proteins induces regression of solid tumours.
Oltersdorf et al.
Nature, 2005;425:677 -
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.
van Delft, MF et al.
Cancer Cell., 2006;10:389 -
ABT-737, an inhibitor of Bcl-2 family proteins, is a potent inducer of apoptosis in multiple myeloma cells.
Kline et al.
Leukemia, 2007;21:1549
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Citation for ABT 737
The citations listed below are publications that use Tocris products. Selected citations for ABT 737 include:
1 Citation: Showing 1 - 1
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Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer's disease.
Authors: Jerome Et al.
Cell Metab 2022;34:1248-1263.e6
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