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ABX 464

Catalog #: 6460 Datasheet / COA / SDS
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6460/10
6460/50
ABX 464 | CAS No. 1258453-75-6 | DNA, RNA and Protein Synthesis Compounds
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Description: HIV RNA splicing modulator

Chemical Name: 8-Chloro-N-[4-(trifluoromethoxy)phenyl]-2-quinolinamine

Purity: ≥98%

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Biological Activity

ABX 464 is an HIV RNA splicing modulator; it selectively enhances the splicing of HIV RNA in infected human PBMCs and inhibits viral replication, with no global effect on cellular splicing. ABX 464 inhibits replication of HIV strains harboring mutations associated with drug-resistance. ABX 464 binds the cap binding complex (CBC) and upregulates miR-124 expression in vitro and decreases expression of miR-124 target genes, MCP-1, CXCL-1, SERPIN-E1 in macrophages. It also decreases the number of Th17 cells, as well as IL-6 soluble receptor in CD4+ T cells. In HIV infected humanized mice, treatment with ABX 464 reduces viral load. Anti-inflammatory.

Technical Data

M.Wt:
338.71
Formula:
C16H10ClF3N2O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1258453-75-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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