Acetazolamide
Chemical Name: N-[5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl]acetamide
Purity: ≥99%
Biological Activity
Acetazolamide is a carbonic anhydrase inhibitor. Modulates epileptiform synchronization in rat brain slices. Increases speed of synaptic vesicle recycling and changes synaptic performance in ex vivo murine neuromuscular junction. Lowers intracranial pressure in healthy rats. Also potentiates the antitumor effects of the HDAC inhibitor MS 275 (Cat. No. 6208).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Acetazolamide potentiates the anti-tumor potential of HDACi, MS-275, in neuroblastoma.
Bayat et al.
BMC Cancer., 2017;17:156 -
Acetazolamide lowers intracranial pressure and modulates the cerebrospinal fluid secretion pathway in healthy rats.
Uldall et al.
Neurosci.Lett., 2017;645:33 -
Carbonic anhydrase inhibitor acetazol. shifts synaptic vesicle recycling to a fast mode at the mouse neuromuscular junction.
Bertone et al.
Synapse., 2017;71 -
Carbonic anhydrase inhibition by acetazol. reduces in vitro epileptiform synchronization.
Hamidi
Neuropharmacology., 2015;95:377
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