Adapalene
Chemical Name: 6-(4-Methoxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid
Purity: ≥98%
Biological Activity
Adapalene is a retinoic acid analog that is a RARβ and RARγ agonist (AC50 values are 2.2, 9.3, 22 and > 1000 nM for RARβ, RARγ, RARα and RXRα receptors respectively). Inhibits proliferation and induces apoptosis in colorectal cancer cell in vitro. Displays comedolytic activity.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Adapalene: an update on newer comparative studies between the various retinoids.
Millikan
Int.J.Dermatol., 2000;39:784 -
Pharmacology and chemistry of adap.
Shroot et al.
J.Am.Acad.Dermatol., 1997;36:S96 -
The synthetic retinoid adap. inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro.
Ocker et al.
Int.J.Cancer, 2003;107:453
Product Datasheets
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Citations for Adapalene
The citations listed below are publications that use Tocris products. Selected citations for Adapalene include:
2 Citations: Showing 1 - 2
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Increased dietary intake of vitamin A promotes aortic valve calcification in vivo.
Authors: Huk Et al.
Arterioscler Thromb Vasc Biol 2013;33:285
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Retinoic acid enhances TRAIL-induced apoptosis in cancer cells by upregulating TRAIL receptor 1 expression.
Authors: Dhandapani Et al.
Drug Des Devel Ther 2011;71:5245
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