ADX 10059 hydrochloride
Chemical Name: 2-[(3-Fluorophenyl)ethynyl]-4,6-dimethyl-3-pyridinamine hydrochloride
Purity: ≥99%
Biological Activity
ADX 10059 hydrochloride is reported to be a negative allosteric modulator at the mGlu5 receptor. Analog of MPEP (Cat. No. 1212).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
6-Aryl-3-pyrrolidinylpyridines as mGlu5 receptor negative allosteric modulators.
Weiss et al.
Bioorg.Med.Chem.Lett., 2011;21:4891 -
A proof-of-concept study evaluating the effect of ADX10059, a metabotropic glutamate receptor-5 negative allosteric modulator, on acid exposure and symptoms in gastro-oesophageal reflux disease.
Keywood et al.
Gut., 2009;58:1192 -
Glutamatergic fine tuning with ADX-10059: a novel therapeutic approach for migraine?
Marin and Goadsby
Expert Opin.Invest.Drugs, 2010;19:555
Product Datasheets
Reconstitution Calculator
Molarity Calculator
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for ADX 10059 hydrochloride
There are currently no reviews for this product. Be the first to review ADX 10059 hydrochloride and earn rewards!
Have you used ADX 10059 hydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
