Home / Cannabinoid Transporter Inhibitors / AM 404

AM 404

Catalog #: 1116
14 Citations 1 Review Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1116/10
1116/50
AM 404 | CAS No. 183718-77-6 | Cannabinoid Transporter Inhibitors
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Description: Anandamide transport inhibitor

Chemical Name: N-(4-Hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetraenamide

Purity: ≥98%

Product Details
Citations (14)
Supplemental Products
Reviews (1)
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

AM 404 is a competitive and selective inhibitor of carrier-mediated anandamide transport (IC50 = 1 μM). Does not activate CB1 receptors or inhibit anandamide hydrolysis but has been shown to activate native and cloned vanilloid receptors (pEC50 = 7.4). Also FABP inhibitor. Active in vivo.

Technical Data

M.Wt:
395.58
Formula:
C26H37NO2
Solubility:
Soluble to 50 mM in ethanol and to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
183718-77-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for AM 404

The citations listed below are publications that use Tocris products. Selected citations for AM 404 include:

14 Citations: Showing 1 - 10

  1. Molecular components and functions of the endocannabinoid system in mouse prefrontal cortex.
    Authors: Lafourcade Et al.
    PLoS One  ;2:e709
  2. AM404, paracetamol metabolite, prevents prostaglandin synthesis in activated microglia by inhibiting COX activity.
    Authors: Saliba
    J Neuroinflammation  2017;14(1):246
  3. Sex Differences in Molecular Signaling at Inhibitory Synapses in the Hippocampus.
    Authors: Tabatadze Et al.
    J Neurosci  2015;35:11252
  4. Effects of cannabinoid drugs on the deficit of prepulse inhibition of startle in an animal model of schizophrenia: the SHR strain.
    Authors: Levin Et al.
    Circulation  2014;5:10
  5. Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses.
    Authors: Caiati Et al.
    Sci Rep  2012;2:285
  6. A putative 'pre-nervous' endocannabinoid system in early echinoderm development.
    Authors: Buznikov Et al.
    Dev Neurosci  2010;32:1
  7. Differential endocannabinoid regulation of baroreflex-evoked sympathoinhibition in normotensive versus hypertensive rats.
    Authors: Brozoski Et al.
    Auton Neurosci  2009;150:82
  8. Blockade of THC-seeking behavior and relapse in monkeys by the cannabinoid CB(1)-receptor antagonist rimon.
    Authors: Justinova Et al.
    Neuropsychopharmacology  2008;33:2870
  9. Characterization of the vasorelaxant mechanisms of the endocannabinoid anandamide in rat aorta.
    Authors: Herradón Et al.
    Br J Pharmacol  2007;152:699
  10. Differential effect of cannabinoid agonists and endocannabinoids on histamine release from distinct regions of the rat brain.
    Authors: Cenni Et al.
    Eur J Neurosci  2006;24:1633

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AM404 administered in vivo works to reduce operant behavior
By Carol Gianessi on 05/23/2019
Species: Mouse

administered to mice prior to operant behavior

use DMSO and Tween 80 to get AM404 into solution

AM404 administered in vivo works to reduce operant behavior 1116
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