Ambrisentan
Chemical Name: (αS)-α-[(4,6-Dimethyl-2-pyrimidinyl)oxy]-β-methoxy-β-phenylbenzenepropanoic acid
Purity: ≥99%
Biological Activity
Ambrisentan is a selective endothelin receptor ETA antagonist. Displays approximately 200-fold selectivity for ETA over ETB (Ki values are 1 nM and 195 nM for respectively). Prevents endothelin-induced sudden death in rats.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Discovery and optimization of a novel class of orally active nonpeptidic endothelin-A receptor antagonists.
Riechers et al.
J.Med.Chem., 1996;39:2123 -
Ambrisentan, a non-peptide endothelin receptor antagonist.
Vatter & Seifert
Cardiovasc.Drug Rev., 2006;24:63
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