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AMD 3465 hexahydrobromide

Catalog #: 4179
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4179/10
4179/50
AMD 3465 hexahydrobromide | CAS No. 185991-07-5 | Chemokine Receptor Antagonists
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Description: Potent and selective CXCR4 antagonist

Chemical Name: N-[[4-(1,4,8,11-Tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-2-pyridinemethanamine hexahydrobromide

Purity: ≥97%

Product Details
Citations (3)
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Biological Activity

AMD 3465 hexahydrobromide is a potent, selective CXCR4 antagonist; exhibits 8-fold higher affinity than AMD 3100 (Cat.No. 3299). Inhibits SDF-1α-ligand binding (Ki = 41.7 nM). Potently inhibits HIV cell entry in vitro; causes leukocytosis and mobilizes haematopoietic stem cells in vivo.

Technical Data

M.Wt:
896.07
Formula:
C24H38N6.6HBr
Solubility:
Soluble to 50 mM in water and to 25 mM in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
185991-07-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for AMD 3465 hexahydrobromide

The citations listed below are publications that use Tocris products. Selected citations for AMD 3465 hexahydrobromide include:

3 Citations: Showing 1 - 3

  1. Crosstalk between astrocytic CXCL12 and microglial CXCR4 contributes to the development of neuropathic pain.
    Authors: Luo Et al.
    Mol Pain  2016;12
  2. Identification of Therapeutic Targets of Inflammatory Monocyte Recruitment to Modulate the Allogeneic Injury to Donor Cornea.
    Authors: David L Et al.
    Invest Ophthalmol Vis Sci  2015;56:7250-9
  3. Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors.
    Authors: Lourenco Et al.
    J Immunol  2015;194:3463

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