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AMG 333

Catalog #: 6874
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6874/10
6874/50
AMG 333 | CAS No. 1416799-28-4 | TRPM Blockers
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Description: Potent and selective TRPM8 antagonist; active in vivo

Chemical Name: 6-[[[(S)-(3-Fluoro-2-pyridinyl)[3-fluoro-4-(trifluoromethoxy)phenyl]methyl]amino]carbonyl]-3-pyridinecarboxylic acid

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

AMG 333 is a potent and selective TRPM8 antagonist (IC50 values are 13 and 20 nM for hTRPM8 and rTRPM8, respectively). Displays high selectivity over other TRP channels (IC50 >20 μM, TRPV1/V3/V4/A1). Inhibits icilin-induced wet-dog shake in rats and suppresses cold-induced increases in blood pressure in the rat cold-pressor test.

Technical Data

M.Wt:
453.33
Formula:
C20H12F5N3O4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1416799-28-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citation for AMG 333

The citations listed below are publications that use Tocris products. Selected citations for AMG 333 include:

1 Citation: Showing 1 - 1

  1. Nebulized Menthol Impairs Mucociliary Clearance via TRPM8 and MUC5AC/MUC5B in Primary Airway Epithelial Cells.
    Authors: Michael D Et al.
    Int J Mol Sci  2023;24

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