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Apoptosis Activator 2

Catalog #: 2098
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2098/10
2098/50
Apoptosis Activator 2 | CAS No. 79183-19-0 | Apoptosis Inducer Compounds
1 Image
Description: Promotes apoptosome formation and activates caspase-9/caspase-3 pathway. Selectively induces tumor cell apoptosis

Chemical Name: 1-[(3,4-Dichlorophenyl)methyl]-1H-indole-2,3-dione

Purity: ≥99%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Apoptosis Activator 2 is an apoptosis activator; promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC50 = 4 - 9 μM for leukemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC50 > 40 μM).

Technical Data

M.Wt:
306.14
Formula:
C15H9Cl2NO2
Solubility:
Soluble to 5 mM in ethanol and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
79183-19-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Elevtaed p75NTR expression causes death of engrailed-deficient midbrain DArgic neurons by Erk1/2 suppression.
    Alavian et al.
    Neural Dev., 2009;4:11
  2. Progesterone attenuates oestrogen neuroprotection via downregulation of oestrogen receptor expression in cultured neurones.
    Jayaraman and Pike
    J.Neuroendocrinol., 2009;21:77
  3. Direct activation of the apoptosis machinery as a mechanism to target cancer cells.
    Nguyen and Wells
    Proc.Natl.Acad.Sci.USA, 2003;100:7533

Product Datasheets

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Citations for Apoptosis Activator 2

The citations listed below are publications that use Tocris products. Selected citations for Apoptosis Activator 2 include:

2 Citations: Showing 1 - 2

  1. SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2.
    Authors: Pan Et al.
    Cell Res  2016;26:190
  2. Hsp70 inhibits heat-induced apoptosis upstream of mitochondria by preventing Bax translocation.
    Authors: Stankiewicz Et al.
    PLoS One  2005;280:38729

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