Home / STAT6 / AS 1517499

AS 1517499

Catalog #: 7636 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7636/10
7636/50
AS 1517499 | CAS No. 919486-40-1 | STAT6
1 Image
Description: STAT6 inhibitor

Chemical Name: 2-[[2-(3-Chloro-4-hydroxyphenyl)ethyl]amino]-4-[(phenylmethyl)amino]-5-pyrimidinecarboxamide

Purity: ≥98%

Product Details
Reviews
Biological Activity Technical Data Product Datasheets Calculators

Biological Activity

AS 1517499 is a potent STAT6 inhibitor (IC50 = 21 nM). In vitro, it inhibits IL-4-induced Th2 differentiation of mouse spleen T cells (IC50 = 2.3 nM), without influencing Th1 differentiation induced by IL-12. In a mouse model of allergic bronchial asthma, treatment with AS 1517499 reduces mouse airway IL-3 production and partly inhibits the RhoA upregulation in bronchial smooth muscles.

Technical Data

M.Wt:
397.86
Formula:
C20H20ClN5O2
Solubility:
Soluble to 50 mM in DMSO and to 10 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
919486-40-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for AS 1517499

There are currently no reviews for this product. Be the first to review AS 1517499 and earn rewards!

Have you used AS 1517499?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.