ATN 161
Purity: ≥95%
Biological Activity
ATN 161 is a α5β1 integrin receptor antagonist. Reduces liver metastasis and improves survival in combination with 5-FU (Cat. No. 3257) in a mouse model of colon cancer. Reduces MLL tumor growth in rats and decreases tumor volume of human MDA-MB-231 cell xenografts in mice.Technical Data
(Modifications: Pro-1 = N-terminal Ac, Asn-5 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Anti-invasive, antitumorigenic, and antimetastatic activities of the PHSCN sequence in prostate carcinoma.
Livant et al.
Cancer Res., 2000;60:309 -
A non-RGD-based integrin binding peptide (ATN-161) blocks breast cancer growth and metastasis in vivo.
Khalili et al.
Mol.Cancer Ther., 2006;5:2271 -
Inhibition of integrin α5β1 function with a small peptide (ATN-161) plus continuous 5-FU infusion reduces colorectal liver metastases and improves survival in mice.
Stoeltzing et al.
Int.J.Cancer., 2003;104:496
Product Datasheets
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Citations for ATN 161
The citations listed below are publications that use Tocris products. Selected citations for ATN 161 include:
4 Citations: Showing 1 - 4
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The interaction of β-arrestin1 with talin1 driven by endothelin A receptor as a feature of α5β1 integrin activation in high-grade serous ovarian cancer.
Authors: Giovanni Et al.
Cell Death Dis 2023;14:73
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Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis.
Authors: Viola Et al.
Elife 2020;9
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Tumor-Derived Extracellular Vesicles Require β1 Integrins to Promote Anchorage-Independent Growth.
Authors: Aejaz Et al.
iScience 2019;14:199-209
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Piezo1 and Gq/G11 promote endothelial inflammation depending on flow pattern and integrin activation.
Authors: Albarrán-Juárez Et al.
J Exp Med 2018;215:2655
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