Avasimibe
Chemical Name: 2,6-Diisopropylphenyl (2-(2,4,6-triisopropylphenyl)acetyl)sulfamate
Purity: ≥98%
Biological Activity
Avasimibe is an ACAT inhibitor (IC50 = 3.3 μM). Inhibits cholesterol esterification and reduces plasma cholesterol levels in rats. Also inhibits tumor growth and prolongs survival time in a melanoma mouse model and reduces tumor growth and metastasis in a pancreatic cancer mouse model.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. CI-1011: an acyl sulfamate with unique cholesterol-lowering activity in animals fed noncholesterol-supplemented diets.
Lee et al.
J.Med.Chem., 1996;39:5031 -
Potentiating the antitumour response of CD8(+) T cells by modulating cholesterol metabolism.
Yang et al.
Nature, 2016;531:651 -
Abrogating cholesterol esterification suppresses growth and metastasis of pancreatic cancer.
Li et al.
Oncogene, 2016;35:6378
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