BF 2649 hydrochloride

Catalog #: 3743 Datasheet / COA / SDS

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BF 2649 hydrochloride | CAS No. 903576-44-3 | Histamine H4 Inverse Agonists

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Description: Potent and selective H3 inverse agonist

Chemical Name: 1-[3-[3-(4-Chlorophenyl)propoxy]propyl]-piperidine hydrochloride

Purity: ≥98%

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Biological Activity

BF 2649 hydrochloride is a potent and selective histamine H₃ receptor inverse agonist (EC₅₀ = 1.5 nM, K_i = 0.16 nM). Exhibits nootropic effects in cognitive disorders; reduces locomotor hyperactivity induced by methamphetamine. Brain penetrant.

Technical Data

M.Wt:

332.31

Formula:

C₁₇H₂₆ClNO.HCl

Solubility:

Soluble to 100 mM in water and to 100 mM in DMSO

Purity:

≥98%

Storage:

Desiccate at RT

CAS No:

903576-44-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Brain histamine and schizophrenia: potential therapeutic applications of H3-receptor inverse agonists studied with BF2.649.
Ligneau et al.
Biochem.Pharmacol., 2007;73:1215
BF2.649 [1-{3-{3-(4-chlorophenyl)propoxy]propyl}piperidine, hydrochloride], a nonimidazole inverse agonist/antagonist at the human histamine H₃ receptor: Preclinical pharmacology.
Ligneau et al.
J.Pharm.Exp.Ther., 2007;320:365

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