Home / Additional Transcription Factor Compounds / BI 6015

BI 6015

Catalog #: 4641
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4641/10
4641/50
BI 6015 | CAS No. 93987-29-2 | Additional Transcription Factor Compounds
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Description: Hepatocyte nuclear factor 4α (HNF4α) antagonist

Chemical Name: 2-Methyl-1-[(2-methyl-5-nitrophenyl)sulfonyl]-1H-benzimidazole

Purity: ≥98%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

BI 6015 is a hepatocyte nuclear factor 4α (HNF4α) antagonist. Represses expression of known HNF4α target genes. Decreases HNF4α DNA binding. Exhibits cytotoxic activity in a range of tumor cell lines, including human hepatocellular carcinoma.

Technical Data

M.Wt:
331.35
Formula:
C15H13N3O4S
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
93987-29-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Reconstitution Calculator

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Citations for BI 6015

The citations listed below are publications that use Tocris products. Selected citations for BI 6015 include:

3 Citations: Showing 1 - 3

  1. Pharmacologic inhibition of HNF4α prevents parenteral nutrition associated cholestasis in mice.
    Authors: David J Et al.
    Sci Rep  2023;13:7752
  2. Berberine Attenuated Proliferation, Invasion and Migration by Targeting the AMPK/HNF4α/WNT5A Pathway in Gastric Carcinoma.
    Authors: Hu Et al.
    Front Pharmacol  2018;9:1150
  3. Nuclear receptors control pro-viral and antiviral metabolic responses to hepatitis C virus infection
    Authors: Levy Et al.
    Nature Chemical Biology  2016;12:1037

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