BL 1249

Catalog #: 3797
2 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
3797/10
3797/50

BL 1249 | CAS No. 18200-13-0 | Two-P Potassium Channels Activators

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Description: K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator

Chemical Name: 5,6,7,8-Tetrahydro-N-[2-(2H-tetrazol-5-yl)phenyl]-1-naphthalenamine

Purity: ≥99%

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Product Details

Citations (2)

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

BL 1249 is a K_2P2.1 (TREK-1) and K_2P10.1 (TREK-2) channel opener (EC₅₀ values are 5.5 μM and 8 μM, respectively). Exhibits selectivity for bladder over vascular tissue in vitro and in vivo (EC₅₀ values are 1.26 and 21.0 μM for cultured bladder and aortic tissues respectively).

Technical Data

M.Wt:

291.35

Formula:

C₁₇H₁₇N₅

Solubility:

Soluble to 100 mM in 1eq. NaOH and to 100 mM in DMSO

Purity:

≥99%

Storage:

Store at -20°C

CAS No:

18200-13-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

BL-1249 [(5,6,7,8-tetrahydro-naphthalen-1-yl)-[2-(1H-tetrazol-5-yl)-phenyl]-amine]: a putative potassium channel opener with bladder-relaxant properties.
Tertyshnikova et al.
J.Pharmacol.Exp.Ther., 2005;313:250
Investigation of the role of TASK-2 channels in rat pulmonary arteries; pharmacological and functional studies following RNA interference procedures.
Gonczi et al.
Br.J.Pharmacol., 2006;147:496
Protein and chemical determinants of BL-1249 action and selectivity for K_2P channels.
Pope et al.
ACS Chem.Neurosci., 2018;9:3153

Product Datasheets

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for BL 1249

The citations listed below are publications that use Tocris products. Selected citations for BL 1249 include:

2 Citations: Showing 1 - 2

TREK-1 and TRAAK Are Principal K+ Channels at the Nodes of Ranvier for Rapid Action Potential Conduction on Mammalian Myelinated Afferent Nerves.
Authors: Koichi Et al.
Neuron 2019;104:960-971.e7
Activation of TREK currents by riluzole in three subgroups of cultured mouse nodose ganglion neurons.
Authors: Fernandez-Fernandez Et al.
PLoS One 2018;13:e0199282

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