Home / Integrin Receptor Inhibitors / BTT 3033

BTT 3033

Catalog #: 4724
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4724/10
4724/50
BTT 3033 | CAS No. 1259028-99-3 | Integrin Receptor Inhibitors
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Description: Selective inhibitor of integrin α2β1

Chemical Name: 1-(4-Fluorophenyl)-N-methyl-N-[4[[(phenylamino)carbonyl]amino]phenyl]-1H-pyrazole-4-sulfonamide

Purity: ≥98%

Product Details
Citations (4)
Supplemental Products
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

BTT 3033 is a selective inhibitor of integrin α2β1 (EC50 = 130 nM for α2β1 binding to collagen I). Binds to the α2I domain. Exhibits selectivity for α2β1 over integrins α3β1, α4β1, α5β1 and αv. BTT 3033 inhibits platelet aggregation to collagen I coated capillaries under flow and inhibits binding of α2-expressing CHO cells to collagen I under shear stress conditions. Neurogenic and thromboxane A2-induced human prostate smooth muscle contraction are also inhibited by BTT 3033.

Technical Data

M.Wt:
465.5
Formula:
C23H20FN5O3S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1259028-99-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for BTT 3033

The citations listed below are publications that use Tocris products. Selected citations for BTT 3033 include:

4 Citations: Showing 1 - 4

  1. How the mechanobiology orchestrates the iterative and reciprocal ECM-cell cross-talk that drives microtissue growth.
    Authors: Gertraud Et al.
    Sci Adv  2023;9:eadd9275
  2. Phosphoproteomics identifies potential downstream targets of the integrin α2β1 inhibitor BTT-3033 in prostate stromal cells.
    Authors: Li Et al.
    Ann.Transl.Med.  2021;9:1380
  3. Collagen I Fibrous Substrates Modulate the Proliferation and Secretome of Estrogen Receptor-Positive Breast Tumor Cells in a Hormone-Restricted Microenvironment.
    Authors: Elaine T Et al.
    ACS Biomater Sci Eng  2021;7:2430-2443
  4. Collagen Type 1 accelerates healing of ruptured fetal membranes.
    Authors: Mogami
    Sci Rep  2018;8(1):696

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