Home / Two-P Potassium Channels Blockers / C 101248

C 101248

Catalog #: 8007 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
8007/50
8007/10
C 101248 | CAS No. 361368-24-3 | Two-P Potassium Channels Blockers
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Description: Selective and potent inhibitor of both mouse and human THIK-1

Chemical Name: 4-[1-(4-Pyridinylmethyl)-1H-benzimidazol-2-yl]-1,2,5-oxadiazol-3-amine

Purity: ≥98%

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Biological Activity

C 101248 is a selective and potent inhibitor of both mouse and human tandem pore domain halothane-inhibited K+ channel 1 (THIK-1, IC50 = 50 nM); it exhibits no activity against K2P family members, TREK-1 and TWIK-2, and Kv2.1. C 101248 blocks both tonic and ATP-evoked THIK-1 K+ currents in whole-cell patch-clamp recordings of mouse hippocampal microglia. C 101248 reduces neuroinflammation by preventing NLRP3-dependent release of IL-1β in isolated microglia.

Technical Data

M.Wt:
292.3
Formula:
C15H12N6O
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
361368-24-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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