Cambinol

Biological Activity

Cambinol is a neutral sphingomyelinase-2 (nSMase2) inhibitor (K_i = 7 μM; IC₅₀ ~ 7.7 μM). In vitro, Cambinol suppresses extracellular vesicle production and inhibits cell-to-cell tau propagation in tau biosensor cells. In vivo, Cambinol decreases tumor necrosis factor-α or interleukin-1β-induced increases of ceramide and cell death in primary neurons. Cambinol is neuroprotective and brain penetrant. Cambinol inhibits the activity of human SIRT1 and SIRT2 and exerts antitumor activity in vitro and in mouse xenograft studies.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties.
   Figuera-Losada et al.
   PLoS One, 2015;10:e0124481

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