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Caspase-2 Inhibitor Z-VDVAD-FMK

Catalog #: FMK003
15 Citations Datasheet / COA / SDS
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FMK003
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Citations (15)
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Summary Product Datasheets Background

Caspase-2 Inhibitor Z-VDVAD-FMK Summary

 

Key Benefits

Cell permeable fluoromethyl ketone (FMK)-derivatized peptides act as effective irreversible Caspase inhibitors with no cytotoxic effects and, therefore, are useful tools for studying Caspase activity.

Specifications

Shipping Conditions
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species
Multi-Species

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Background: Caspase-2

Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7).

Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi. Cell-permeable and irreversible peptide inhibitors are also available for different caspases.

Entrez Gene IDs
835 (Human); 12366 (Mouse)
Alternate Names
caspase-2; CASP2; CASP-2; caspase 2, apoptosis-related cysteine peptidase; Caspase2; Caspase-2; ICH1; ICH-1; NEDD2; NEDD-2; PPP1R57

Citations for Caspase-2 Inhibitor Z-VDVAD-FMK

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

15 Citations: Showing 1 - 10
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  1. The exon-junction complex helicase eIF4A3 controls cell fate via coordinated regulation of ribosome biogenesis and translational output
    Authors: DC Kanellis, JA Espinoza, A Zisi, E Sakkas, J Bartkova, AM Katsori, J Boström, L Dyrskjøt, H Broholm, M Altun, SJ Elsässer, MS Lindström, J Bartek
    Science Advances, 2021-08-04;7(32):.  2021-08-04
  2. A Switch in p53 Dynamics Marks Cells That Escape from DSB-Induced Cell Cycle Arrest
    Authors: M Tsabar, CS Mock, V Venkatacha, J Reyes, KW Karhohs, TG Oliver, A Regev, A Jambhekar, G Lahav
    Cell Rep, 2020-08-04;32(5):107995.  2020-08-04
  3. Osteogenic impact of pro-apoptotic caspase inhibitors in MC3T3-E1 cells
    Authors: A Kratochvíl, B Veselá, V Ledvina, E Švandová, K Klepárník, K Dadáková, P Beneš, E Matalová
    Sci Rep, 2020-05-04;10(1):7489.  2020-05-04
  4. The mechanism of how CD95/Fas activates the Type I IFN/STAT1 axis, driving cancer stemness in breast cancer
    Authors: AS Qadir, AM Stults, AE Murmann, ME Peter
    Sci Rep, 2020-01-28;10(1):1310.  2020-01-28
  5. PLOD3 suppression exerts an anti-tumor effect on human lung cancer cells by modulating the PKC-delta signaling pathway
    Authors: JH Baek, HS Yun, GT Kwon, J Lee, JY Kim, Y Jo, JM Cho, CW Lee, JY Song, J Ahn, JS Kim, EH Kim, SG Hwang
    Cell Death Dis, 2019-02-15;10(3):156.  2019-02-15
  6. Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells
    Authors: E Alharris, NP Singh, PS Nagarkatti, M Nagarkatti
    Oncotarget, 2019-01-01;10(1):45-59.  2019-01-01
  7. Macrophage Apoptosis Triggered by IpaD from Shigella flexneri
    Authors: O Arizmendi, WD Picking, WL Picking
    Infect Immun, 2016-05-24;0(0):.  2016-05-24
  8. The Topoisomerase 1 Inhibitor Austrobailignan-1 Isolated from Koelreuteria henryi Induces a G2/M-Phase Arrest and Cell Death Independently of p53 in Non-Small Cell Lung Cancer Cells.
    Authors: Wu C, Huang K, Yang T, Li Y, Wen C, Hsu S, Chen T
    PLoS ONE, 2015-07-06;10(7):e0132052.  2015-07-06
  9. Transfection of poly(I:C) can induce reactive oxygen species-triggered apoptosis and interferon-beta-mediated growth arrest in human renal cell carcinoma cells via innate adjuvant receptors and the 2-5A system.
    Authors: Harashima N, Minami T, Uemura H, Harada M
    Mol Cancer, 2014-09-17;13(0):217.  2014-09-17
  10. 5-Fluorouracil-induced apoptosis in colorectal cancer cells is caspase-9-dependent and mediated by activation of protein kinase C-delta
    Authors: Mhaidat N, Bouklihacene M, Thorne R
    Oncol Lett, 2014-06-02;8(2):699-704.  2014-06-02
  11. Caspase-2 maintains bone homeostasis by inducing apoptosis of oxidatively-damaged osteoclasts.
    Authors: Sharma, Ramaswam, Callaway, Danielle, Vanegas, Difernan, Bendele, Michelle, Lopez-Cruzan, Marisa, Horn, Diane, Guda, Teja, Fajardo, Roberto, Abboud-Werner, Sherry, Herman, Brian
    PLoS ONE, 2014-04-01;9(4):e93696.  2014-04-01
  12. Inhibition of cancer cell proliferation and apoptosis-inducing activity of fungal taxol and its precursor baccatin III purified from endophytic Fusarium solani.
    Authors: Chakravarthi B, Sujay R, Kuriakose G, Karande A, Jayabaskaran C
    Cancer Cell Int, 2013-10-23;13(1):105.  2013-10-23
  13. Association of a single dose of gonadotropin-releasing hormone antagonist with nitric oxide and embryo quality in in vitro fertilization cycles.
    Authors: Lee TH, Wu MY, Chen HF, Chen SU, Ho HN, Yang YS
    Fertil. Steril., 2006-09-11;86(4):1020-2.  2006-09-11
  14. Mechanism of induction of pancreatic acinar cell apoptosis by hydrogen sulfide.
    Authors: Cao Y, Adhikari S, Ang AD, Moore PK, Bhatia M
    Am. J. Physiol., Cell Physiol., 2006-04-05;291(3):C503-10.  2006-04-05
  15. Enhancement of stress-induced apoptosis in B-lineage cells by caspase-9 inhibitor.
    Authors: Shah N, Asch RJ, Lysholm AS, Lebien TW
    Blood, 2004-07-08;104(9):2873-8.  2004-07-08

FAQs

  1. Does R&D Systems offer a negative control for Caspase Inihibitors with benzyloxycarbonyl group (Z-) at the N-terminus and the FMK functional group at the C-terminus?

    • Yes, R&D Systems offers Caspase Inhibitor Control Z-FA-FMK, Catalog # FMKC01, which is an inhibitor of cathepsins B and L but not caspases, and has been used in several systems as a negative control for peptide inhibitors of caspases.

  2. Are R&D Systems Caspase Inhibitors irreversible?

    • Yes, the majority of R&D Systems Caspase Inhibitors have a Fluoromethyl ketone (FMK) functional group on the C-terminus of the peptide, and act as effective irreversible inhibitors with no added cytotoxic effects. Inhibitors synthesized with a benzyloxycarbonyl group (also known as BOC or Z) at the N-terminus and O-methyl side chains exhibit enhanced cellular permeability.

      R&D Systems also offers a General Caspase Inhibitor, Q-VD-OPh, Catalog # OPH001, as well as a FITC-conjugated pan-caspase inhibitor (ApoStat), Catalog # FMK012, which are both cell-permeable, irreversible inhibitors of caspase activity.

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