CDPPB
Chemical Name: 3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide
Purity: ≥98%
Biological Activity
CDPPB is a brain penetrant, selective positive allosteric modulator at the mGlu5 receptor (EC50 values are 10 and 20 nM for human and rat receptors respectively). Antipsychotic; reverses amphetamine-induced locomotor activity and amphetamine-induced deficits in prepulse inhibition in rats.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses.
Chen et al.
Mol.Pharmacol., 2007;71:1389 -
Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides that potentiate receptor function in vivo.
Lindsley et al.
J.Med.Chem., 2004;47:5825 -
A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rats behavioral models.
Kinney et al.
J.Pharmacol.Exp.Ther., 2005;313:199
Product Datasheets
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Citations for CDPPB
The citations listed below are publications that use Tocris products. Selected citations for CDPPB include:
5 Citations: Showing 1 - 5
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A positive allosteric modulator of mGluR5 promotes neuroprotective effects in mice models of Alzheimer's disease.
Authors: Bellozi Et al.
Neuropharmacology. 2019;160:107785
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Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice.
Authors: Vicidomini Et al.
Mol Psychiatry 2017;22:689
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OE Facilitation of Cocaine Self-Administration in Female Rats Requires Activation of mGluR5.
Authors: Martinez Et al.
Eneuro 2016;3
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Loss of Metabotropic Glutamate Receptor 5 Function on Peripheral Benzodiazepine Receptor in Mice Prenatally Exposed to LPS.
Authors: Arsenault Et al.
PLoS One 2015;10:e0142093
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Subchronic administration and combination metabotropic glutamate and GABAB receptor drug therapy in fragile X syndrome.
Authors: Pacey Et al.
Front Pharmacol 2011;338:897
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