Celastrol
Chemical Name: (9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid
Purity: ≥99%
Biological Activity
Celastrol is an antioxidant and anti-inflammatory agent. Potently inhibits lipid peroxidation in mitochondria and inhibits TNF-α-induced NFκB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 μM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Apoptosis induction in HL-60 cells and inhibition of topoisomerase II by triterpene celastrol.
Nagase et al.
Biosci.Biotechnol.Biochem., 2003;67:1883 -
Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-κB-regulated gene products and TAK1-mediated NF-κB activation.
Sethi et al.
Blood, 2007;109:2727 -
The triterpene celastrol as a very potent inhibitor of lipid peroxidation in mitochondria.
Sassa et al.
Biochem.Biophys.Res.Comms., 1990;172:890
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Citation for Celastrol
The citations listed below are publications that use Tocris products. Selected citations for Celastrol include:
1 Citation: Showing 1 - 1
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Interleukin 34: a new modulator of human and experimental inflammatory bowel disease.
Authors: Zwicker Et al.
Clin Sci (Lond) 2015;129:281
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