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CGP 46381

Catalog #: 1247
5 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1247/10
1247/50
CGP 46381 | CAS No. 123691-14-5 | GABA-B Receptor Antagonists
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Description: Selective GABAB antagonist; brain penetrant

Chemical Name: (3-Aminopropyl)(cyclohexylmethyl)phosphinic acid

Product Details
Citations (5)
Supplemental Products
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

CGP 46381 is a brain penetrant, selective GABAB receptor antagonist (IC50 = 4.9 μM).

Technical Data

M.Wt:
219.26
Formula:
C10H22NO2P
Solubility:
Soluble to 100 mM in water
Storage:
Store at RT
CAS No:
123691-14-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of Novartis Pharma AG

Background References

  1. Prolonged GABAB receptor-mediated synaptic inhibition in the cat spinal cord: an in vivo study.
    Curtis and Lacey
    Exp.Brain Res., 1998;121:319
  2. GABAB receptor antagonism: facilitatory effects on memory parallel those on LTP induced by TBS but not HFS.
    Staubli et al.
    J.Neurosci., 1999;19:4609
  3. Blockade of the late inhibitory postsynaptic potential in vivo by the GABAB antagonist CGP 46381.
    Lingenhoehl and Olpe
    Pharmacol.Comm., 1993;3:49
  4. Potent, orally active GABAB receptor antagonists.
    Froestl et al.
    Pharmacol.Rev.Comm., 1996;8:127

Product Datasheets

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Citations for CGP 46381

The citations listed below are publications that use Tocris products. Selected citations for CGP 46381 include:

5 Citations: Showing 1 - 5

  1. 17β-OE Acutely Potentiates Glutamatergic Synaptic Transmission in the Hippocampus through Distinct Mechanisms in Males and Females.
    Authors: Oberlander
    J Neurosci  2016;36:2677
  2. GABAB receptor antagonist CGP46381 inhibits form-deprivation myopia development in guinea pigs.
    Authors: Cheng Et al.
    Front Cell Neurosci  2015;2015:207312
  3. Intrinsic modulators of auditory thalamocortical transmission.
    Authors: Lee and Sherman
    Hear Res  2012;287:43
  4. Subchronic administration and combination metabotropic glutamate and GABAB receptor drug therapy in fragile X syndrome.
    Authors: Pacey Et al.
    Biomed Res Int  2011;338:897
  5. Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition.
    Authors: Costa Et al.
    J Neurosci  2008;28:8040

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