Home / GPR55 Receptor Antagonists / CID 16020046

CID 16020046

Catalog #: 4959
6 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4959/5
4959/25
CID 16020046 | CAS No. 834903-43-4 | GPR55 Receptor Antagonists
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Description: Selective GPR55 antagonist

Chemical Name: 4-[4,6-Dihydro-4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxopyrrolo[3,4-c]pyrazol-5(1H)-yl]benzoic acid

Purity: ≥99%

Product Details
Citations (6)
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Biological Activity

CID 16020046 is a selective GPR55 antagonist. Inhibits LPI-induced Ca2+ signaling (IC50 = 0.21 μM in HEK-GPR55 cells), ERK1/2 phosphorylation and GPR55-mediated transcription factor activation. Displays weak inhibition of acetylcholinesterase, μ-opioid receptor, KCNH2 and hERG. Decreases LPI-induced GPR55 internalization. Reduces experimental intestinal inflammation in mice.

Technical Data

M.Wt:
425.44
Formula:
C25H19N3O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
834903-43-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for CID 16020046

The citations listed below are publications that use Tocris products. Selected citations for CID 16020046 include:

6 Citations: Showing 1 - 6

  1. THC Reduces Ki67-Immunoreactive Cells Derived from Human Primary Glioblastoma in a GPR55-Dependent Manner.
    Authors: Ken Et al.
    Cancers (Basel)  2021;13
  2. A novel crosstalk within the endocannabinoid system controls GABA transmission in the striatum.
    Authors: Musella
    Sci Rep  2017;7(1):7363
  3. Lysophosphatidylcholine elicits intracellular calcium signaling in GPR55-dependent manner
    Authors: Drzazga
    Biochem Biophys Res Commun  2017;489(2):242
  4. The novel cannabinoid receptor GPR55 mediates anxiolytic-like effects in the medial orbital cortex of mice with acute stress.
    Authors: Shi
    Mol Brain  2017;10(1):38
  5. Anandamide, Acting via CB2 Receptors, Alleviates LPS-Induced Neuroinflammation in Rat Primary Microglial Cultures.
    Authors: Katarzyna Et al.
    Neural Plast  2015;2015:130639
  6. The GPR 55 agonist, L-α-lysophosphatidylinositol, mediates ovarian carcinoma cell-induced angiogenesis.
    Authors: Hofmann Et al.
    Br J Pharmacol  2015;172:4107

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