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Cilnidipine

Catalog #: 2629 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2629/10
2629/50
Cilnidipine | CAS No. 132203-70-4 | Cav1.x Channel Blockers
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Description: Dual CaV1.x and CaV2.x blocker
Alternative Names: FRC 8653

Chemical Name: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester

Purity: ≥99%

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Biological Activity

Cilnidipine is a dual L- and N-type calcium channel blocker that displays antihypertensive, sympatholytic and neuroprotective activity. Lowers mean blood pressure and reduces the size of cerebral infarction in the rat model of focal brain ischemia.

Technical Data

M.Wt:
492.52
Formula:
C27H28N2O7
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
132203-70-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Preferential inhibition of L- and N-type calcium channels in the rat hippocampal neurons by cilnidipine.
    Murai et al.
    Brain Res., 2000;854:6
  2. Neuroprotective effects of a dual L/N-type Ca2+ channel blocker cilnidipine in the rat focal brain ischemia model.
    Takahara et al.
    Biol.Pharm.Bull., 2004;27:1388
  3. The evaluation of the N-type channel blocking properties of cilnidipine and other voltage-dependent calcium antagonists.
    Nap et al.
    Fund.Clin.Pharmacol., 2004;18:309

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