CIM 0216
Chemical Name: 3,4-Dihydro-N-(5-methyl-3-isoxazolyl)-α-phenyl-1(2H)-quinolineacetamide
Purity: ≥98%
Biological Activity
CIM 0216 is a selective TRPM3 agonist. Exhibits selectivity for TRPM3 over TRPM1, TRPM2 and TRPM4-8. Stimulates insulin release from pancreatic islet cells in vitro. Evokes nocifensive behavior in mice.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Activation of TRPM3 by a potent synthetic ligand reveals a role in peptide release.
Held et al.
Proc.Natl.Acad.Sci.U.S.A., 2015;112:E1363
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Citations for CIM 0216
The citations listed below are publications that use Tocris products. Selected citations for CIM 0216 include:
2 Citations: Showing 1 - 2
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ATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking.
Authors: Xi Et al.
Nat Commun 2021;12:1401
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Activation of gene transcription via CIM0216, a synthetic ligand of transient receptor potential melastatin-3 (TRPM3) channels.
Authors: Rubil and Thiel
Channels (Austin) 2017;11:79
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