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Cinacalcet hydrochloride

Catalog #: 6170
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6170/50
6170/10
Cinacalcet hydrochloride | CAS No. 364782-34-3 | Calcium-Sensing Receptor Agonists
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Description: Allosteric Calcium-sensing receptor (CaSR) agonist; also CYP2D2 inhibitor and Ca2+ channel blocker; orally bioavailable
Alternative Names: AMG 073

Chemical Name: N-[(1R)-1-(1-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine hydrochloride

Purity: ≥98%

Product Details
Citations (2)
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Biological Activity

Cinacalcet hydrochloride is a calcium-sensing receptor (CaSR) allosteric agonist. Activates CaSR signaling in cellular proliferation and phosphatidylinositol (PI) hydrolysis assays. Reduces serum parathyroid hormone levels in rats. Also potent CYP2D2 inhibitor (IC50 = 87 nM) and L-type calcium channel blocker. Orally bioavailable.

Technical Data

M.Wt:
393.87
Formula:
C22H22F3N.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
364782-34-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Cinacalcet hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Cinacalcet hydrochloride include:

2 Citations: Showing 1 - 2

  1. Asymmetric dimethylarginine positively modulates calcium-sensing receptor signalling to promote lipid accumulation.
    Authors: Ian P Et al.
    Cell Signal  2023;107:110676
  2. Area Postrema Cell Types that Mediate Nausea-Associated Behaviors.
    Authors: Stephen D Et al.
    Neuron  2021;109:461-472.e5

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