Clotrimazole
Chemical Name: 1-(2-Chloro-α,α-diphenylbenzyl)imidazole
Purity: ≥99%
Biological Activity
Clotrimazole is an imidazole antimycotic and cytochrome P450 inhibitor. Inhibits Ca2+-activated K+ current (IC50 = 3 μM) and L-type Ca2+ current; increases the firing rate of action potentials. Exhibits antiproliferative activity in vitro and in vivo. Also an inverse agonist of the human constitutive androstane receptor (hCAR).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Antagonist- and inverse agonist-driven interactions of the vitamin D receptor and the constitutive androstane receptor with corepressor protein.
Lempiainen et al.
Mol.Endocrinol., 2005;19:2258 -
Clomitrazole, an antimycotic drug, inhibits the sarcoplasmic reticulum calcium pump and contractile function in heart muscle.
Snajdrova et al.
J.Biol.Chem., 1998;273:28032 -
Inhibition of Ca2+-activated K+ current by clotrimazole in rat anterior pituitary GH3 cells.
Wu et al.
Neuropharmacology, 1999;38:979 -
The antifungal antibiotic clotrimazole potently inhibits L-type calcium current in guinea-pig ventricular myocytes.
Thomas et al.
Br.J.Pharmacol., 1999;126:1531
Product Datasheets
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Citations for Clotrimazole
The citations listed below are publications that use Tocris products. Selected citations for Clotrimazole include:
3 Citations: Showing 1 - 3
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TREK channel activation suppresses migraine pain phenotype.
Authors: Anne-Amandine Et al.
iScience 2021;24:102961
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Pseudomonas aeruginosa-induced nociceptor activation increases susceptibility to infection.
Authors: Rossen Et al.
PLoS Pathog 2021;17:e1009557
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Neuronal complexity is attenuated in preclinical models of migraine and restored by HDAC6 inhibition.
Authors: Mark M Et al.
Elife 2021;10
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