Conivaptan hydrochloride
Chemical Name: N-[4-[(4,5-Dihydro-2-methylimidazo[4,5-d][benzazepin-6(1H)-yl)carbonyl]phenyl-[1,1'-biphenyl]-2-carboxamide hydrochloride
Purity: ≥98%
Biological Activity
Conivaptan hydrochloride is a very high affinity vasopressin V1A and V2 antagonist (Ki values are 0.61 and 0.66 - 3.04 nM, respectively). Inhibits vasopressin-induced pressor responses in rats without altering blood pressure, and increases urine flow while decreasing urine osmolality. Orally bioavailable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Pharmacological profile of YM087, a novel potent nonpeptide vasopressin V1A and V2 receptor antagonist, in vitro and in vivo.
Tahara et al.
J.Pharmacol.Exp.Ther., 1997;282:301 -
Pharmacological profile of YM087, a novel nonpeptide dual vasopressin V1A and V2 receptor antagonist, in dogs.
Yatsu et al.
Eur.J.Pharmacol., 1997;321:225
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