CRF (human, rat)
Purity: ≥95%
Biological Activity
CRF (human, rat) is a endogenous peptide agonist for the CRF receptor (Ki values are 11, 44 and 38 nM for hCRF1, rCRF2a and mCRF2b respectively). Stimulates the synthesis and release of ACTH from the anterior pituitary.Technical Data
(Modifications: Ile-41 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Comparison of an agonist, urocortin, and an antagonist, astressin, as radioligands for characterization of corticotropin-releasing factor receptors.
Perrin et al.
J.Pharmacol.Exp.Ther., 1999;288:729 -
Corticotropin releasing factor receptors and their ligand family.
Perrin and Vale
Ann.N.Y.Acad.Sci., 1999;885:312 -
Corticotropin-releasing factor receptors in rat forebrain: autoradiographic identification.
Souza et al.
Science, 1984;224:1449 -
Inhibition of gastric acid secretion in rats by intracerebral injection of corticotropin-releasing factor.
Tache et al.
Science, 1983;222:935 -
Mediation by cortico. releasing factor (CRF) of adenohypophysial hormone secretion.
Rivier et al.
Annu.Rev.Physiol., 1986;48:475 -
Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of cortico. and β-endorphin.
Vale et al.
Science, 1981;213:1394
Product Datasheets
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Citations for CRF (human, rat)
The citations listed below are publications that use Tocris products. Selected citations for CRF (human, rat) include:
10 Citations: Showing 1 - 10
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Exchange protein directly activated by cAMP 2 is required for CRH-releasing hormone-mediated spine loss.
Authors: Xie Et al.
Eur J Neurosci 2019;
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Deciphering the Contributions of CRH Receptors in the Brain and Pituitary to Stress-Induced Inhibition of the Reproductive Axis.
Authors: Raftogianni Et al.
Front Mol Neurosci 2018;11:305
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CRF-R1 activation in the anterior-dorsal BNST induces maternal neglect in lactating rats via an HPA axis-independent central mechanism.
Authors: Klampfl Et al.
J Neuroinflammation 2016;64:89
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Systemic pro-inflammatory response facilitates the development of cerebral edema during short hypoxia.
Authors: Song Et al.
J Neurosci 2016;13:63
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Orexin-corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine.
Authors: Navarro Et al.
Psychoneuroendocrinology 2015;35:6639
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Corticotropin-releasing hormone drives anandamide hydrolysis in the amygdala to promote anxiety.
Authors: Gray Et al.
J Neurosci 2015;35:3879
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Corticotropin releasing factor and catecholamines enhance glutamatergic neurotransmission in the lateral subdivision of the central amygdala.
Authors: Silberman and Winder
Neuropharmacology 2013;70:316
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Corticotropin releasing factor signaling in the central amygdala is recruited during binge-like ethanol consumption in C57BL/6J mice.
Authors: Lowery-Gionta Et al.
J Neurosci 2012;32:3405
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The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system.
Authors: Land Et al.
J Neurosci 2008;28:407
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Corticotropin-releasing factor (CRF) and the urocortins differentially regulate catecholamine secretion in human and rat adrenals, in a CRF receptor type-specific manner.
Authors: Dermitzaki Et al.
Endocrinology 2007;148:1524
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