CTCE 9908
Purity: ≥95%
Biological Activity
CTCE 9908 is a CXCR4 antagonist; induces mitotic catastrophe in ovarian cancer cells. Displays additive cytotoxic effects when given with taxol (Cat. No. 1097). Enhances the efficacy of docetaxel (Cat. No. 4056) in a mouse model.Technical Data
(Modifications: Amide bridge = 9-8*, Lys-9 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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An antagonist of the chemokine receptor CXCR4 induces mitotic catastrophe in ovarian cancer cells.
Kwong et al.
Mol.Cancer Ther., 2009;8:1893 -
The many facets of SDF-1alpha, CXCR4 agonists and antagonists on hematopoietic progenitor cells.
Faber et al.
J.Biomed.Biotechnol., 2007;2007:26065 -
CXCR4 peptide antagonist inhibits primary breast tumor growth, metastasis and enhances the efficacy of anti-VEGF treatment or doce. in a transgenic mouse model.
Hassan et al.
Int.J.Cancer., 2011;129:225
Product Datasheets
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Citation for CTCE 9908
The citations listed below are publications that use Tocris products. Selected citations for CTCE 9908 include:
1 Citation: Showing 1 - 1
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Microtiter plate-based antibody-competition assay to determine binding affinities and plasma/blood stability of CXCR4 ligands.
Authors: Ludger Et al.
Sci Rep 2020;10:16036
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