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CU-76

Catalog #: 7820 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7820/2
CU-76 | CAS No. 2400954-58-5 | STING/TMEM173
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Description: Selective inhibitor of cyclic GMP-AMP synthase (cGAS)

Chemical Name: Methyl 4-amino-6-[(3,5-difluoro-4-iodophenyl)amino]-1,3,5-triazine-2-carboxylate

Purity: ≥98%

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Biological Activity

CU-76 is a selective cyclic GMP-AMP synthase (cGAS) inhibitor (IC50 = 0.24 μM). It specifically inhibits cGAS-STING pathway and has no effect on other nucleic acid sensing pathways such as the RIG-I-MAVS or Toll-like receptor pathways. CU-76 reduces DNA-induced IFN regulatory factor 3 (IRF3) dimerization in a dose-dependent manner, and it decreases production of IFN-β in THP-1 cells stimulated with interferon-stimulatory DNA.

Technical Data

M.Wt:
407.12
Formula:
C11H8F2IN5O2
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2400954-58-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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