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CU CPT 22

Catalog #: 4884
5 Citations Datasheet / COA / SDS
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4884/10
4884/50
CU CPT 22 | CAS No. 1416324-85-0 | Toll-like Receptor Inhibitors
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Description: Selective TLR1/2 inhibitor

Chemical Name: 3,4,6-Trihydroxy-2-methoxy-5-oxo-5H-benzocycloheptene-8-carboxylic acid hexyl ester

Purity: ≥98%

Product Details
Citations (5)
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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

CU CPT 22 is a selective toll-like receptor 1/2 (TLR1/2) inhibitor (IC50 = 0.58 μM). Exhibits no activity at TLR2/TLR6, TLR3, TLR4 and TLR7 or a panel of 10 representative kinases. Inhibits the release of proinflammatory cytokines TNF-α and IL-1β.

Technical Data

M.Wt:
362.37
Formula:
C19H22O7
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1416324-85-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from the University of Colorado

Background References

  1. Discovery of small-molecule inhibitors of the TLR1/TLR2 complex.
    Cheng et al.
    Angew Chem.Int.Ed.Engl., 2012;51:12246

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Citations for CU CPT 22

The citations listed below are publications that use Tocris products. Selected citations for CU CPT 22 include:

5 Citations: Showing 1 - 5

  1. TLR4 activation by lysozyme induces pain without inflammation.
    Authors: Avadhesha Et al.
    Front Immunol  2023;14:1065226
  2. Toll-like receptor 2 promotes breast cancer progression and resistance to chemotherapy.
    Authors: Pietro Et al.
    Oncoimmunology  2022;11:2086752
  3. Monocytes enhance the inflammatory response to TLR2 stimulation in aortic valve interstitial cells through paracrine up-regulation of TLR2 level.
    Authors: Balachandar Et al.
    Int J Biol Sci  2020;16:3062-3074
  4. Nonsaponin fraction of Korean Red Ginseng attenuates cytokine production via inhibition of TLR4 expression.
    Authors: Ahn Et al.
    J Ginseng Res  2019;43:291
  5. Inflammasome priming is similar for francisella species that differentially induce inflammasome activation.
    Authors: Ghonime Et al.
    Nucleic Acids Res  2015;10:e0127278

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