Cyclosomatostatin
Purity: ≥95%
Biological Activity
Cyclosomatostatin is a non-selective somatostatin (sst) receptor antagonist. Blocks the effects of sst on airway β-adrenergic function, CRF-induced suppression of gastric empyting, modulation of ACh release and growth hormone, insulin and glucagon release. Reported to act as an sst receptor agonist in human neuroblastoma cell line SH-SY5Y.Technical Data
(Modifications: Phe-1 = Aminoheptanoyl-Phe, Trp-2 = D-Trp, Thr-4 = Bn-Thr)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Somatostatin antagonist analog increases GH, Ins, and glucagon release in the rat.
Fries et al.
Peptides, 1982;3:811 -
The putative somatostatin antagonist, cyclo-(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[BZL]), may act as a potent antiproliferative agonist.
Stirnweis et al.
Peptides, 2002;23:1503 -
Somatostatin inhibits activation of dorsal cutaneous primary afferents induced by antidromic stimulation of primary afferents from an adjacent segment in the rat.
Guo et al.
Brain Res., 2008;1229:61
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Citations for Cyclosomatostatin
The citations listed below are publications that use Tocris products. Selected citations for Cyclosomatostatin include:
5 Citations: Showing 1 - 5
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Somatostatin-evoked Aβ catabolism in the brain: Mechanistic involvement of α-endosulfine-KATP channel pathway.
Authors: Takashi Et al.
Mol Psychiatry 2022;27:1816-1828
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Enhanced neprilysin-mediated degradation of hippocampal Aβ42 with a somatostatin peptide that enters the brain.
Authors: Chiara Et al.
Theranostics 2021;11:789-804
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Somatostatin enhances visual processing and perception by suppressing excitatory inputs to parvalbumin-positive interneurons in V1.
Authors: Anaëlle Et al.
Sci Adv 2020;6:eaaz0517
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APC mutations in human colon lead to decreased neuroendocrine maturation of ALDH+ stem cells that alters GLP-2 and SST feedback signaling: Clue to a link between WNT and retinoic acid signalling in colon cancer development.
Authors: Tao Et al.
PLoS One 2020;15:e0239601
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Somatostatin and Ins mediate glucose-inhibited glucagon secretion in the pancreatic α-cell by lowering cAMP.
Authors: Elliott Et al.
Am J Physiol Endocrinol Metab 2015;308:E130
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