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DHC-156

Catalog #: 8168 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
8168/5
DHC-156 | Additional Transcription Factor Compounds
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Description: Brachyury down modulator

Chemical Name: (E)-4-(Dimethylamino)-N-[1-[4-fluoro-3-(2,2,2-trifluoroethoxy)anilino]-6-methoxy-7-isoquinolyl]but-2-enamide

Purity: ≥98%

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Biological Activity

DHC-156 is a brachyury down modulator (DC50 = 4.1 μM, DMax > 99% at 10 μM). DHC-156 down modulates brachyury post-translationally, in a proteasome- and lysosome-independent manner. DHC-156 down modulation of brachyury results in an irreversible impairment of chordoma tumor cell growth.

Technical Data

M.Wt:
492.47
Formula:
C24H24F4N4O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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