Dihydroergotamine mesylate

Catalog #: 0475 Datasheet / COA / SDS

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Dihydroergotamine mesylate | CAS No. 6190-39-2 | Non-selective Adrenergic alpha Receptor Agonists

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Description: α partial agonist; also D2-like partial agonist and 5-HT antagonist

Chemical Name: 9,10-Dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)ergotaman-3',6',18-trione mesylate

Purity: ≥98%

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Biological Activity

Dihydroergotamine mesylate is a partial α-adrenergic agonist. Partial D₂ dopaminergic receptor agonist. Competitive 5-HT antagonist.

Technical Data

M.Wt:

679.79

Formula:

C₃₃H₃₇N₅O₅.CH₃SO₃H

Solubility:

Soluble to 100 mM in DMSO

Purity:

≥98%

Storage:

Store at RT

CAS No:

6190-39-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Further analysis of the inhibitory effects of dihydroergotamine, cyprohept. and ketanserin on the responses of the rat aorta to 5-hydroxytryptamine.
Doggrell et al.
J.Auton.Pharmacol., 1992;12:223
Carotid vascular effects of ergot. and dihydroergot. in the pig: no exclusive mediation via 5-HT₁-like receptors.
de Boer et al.
Br.J.Pharmacol., 1991;104:183
Agonistic properties of alniditan, sumatr. and dihydroergot. on human 5-HT_1B and 5-HT_1D receptors expressed in various mammalian cell lines.
Lesage et al.
Br.J.Pharmacol., 1998;123:1655
Effects of S9977 and dihydroergot. in an animal experimental model for migraine.
Villalon et al.
Pharmacol.Res., 1992;25:125

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

⚠ WARNING: This product can expose you to chemicals including Dihydroergotamine mesylate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

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