Home / Cyclin-dependent Kinase Inhibitors / Dinaciclib

Dinaciclib

Catalog #: 7336 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7336/10
7336/50
Dinaciclib | CAS No. 779353-01-4 | Cyclin-dependent Kinase Inhibitors
1 Image
Description: Potent and selective inhibitor of CDK2, CDK5, CDK1 and CDK9
Alternative Names: SCH 727965

Chemical Name: (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol

Purity: ≥98%

Product Details
Reviews
Biological Activity Technical Data Product Datasheets Calculators

Biological Activity

Dinaciclib is a potent and selective inhibitor of CDK2, CDK5, CDK1 and CDK9 activity in vitro (IC50 values are 1, 1, 3 and 4 nM, respectively). The compound inhibits DNA replication by blocking thymidine DNA incorporation in A2780 cells (IC50 = 4 nM). Dinaciclib induces regression of established solid tumors in mouse models and shows antiviral activity against SARS-CoV-2 in vitro (Vero E6, IC50 = 0.127 μM; A549-ACE2, IC50 = 0.032 μM).

Technical Data

M.Wt:
396.5
Formula:
C21H28N6O2
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
779353-01-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Dinaciclib

There are currently no reviews for this product. Be the first to review Dinaciclib and earn rewards!

Have you used Dinaciclib?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.