DL 175
Chemical Name: 3-(2-((4-Chloronaphthalen-1-yl)oxy)ethyl)pyridine 1-oxide
Purity: ≥98%
Biological Activity
DL 175 is a potent and selective GPR84 biased agonist (EC50 = 33 nM). Exhibits no significant activity in a panel of 168 other GPCRs. Exhibits bias for G protein signaling pathways. Induces morphological changes in primary murine bone marrow-derived macrophages (BMDMs) in a cellular impedance assay, and promotes phagocytosis by M1 polarized U937 cells. Induces migration of primary human monocytes, but has no effect on macrophage chemotaxis.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A biased agonist at immunometabolic receptor GPR84 causes distinct functional effects in macrophages.
Lucy et al.
ACS Chem.Biol, 2019;14:2055
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Citation for DL 175
The citations listed below are publications that use Tocris products. Selected citations for DL 175 include:
1 Citation: Showing 1 - 1
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Selective phosphorylation of threonine residues defines GPR84-arrestin interactions of biased ligands.
Authors: Marsango Et al.
J.Biol.Chem. 2022;298:101932
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