DMCM hydrochloride
Chemical Name: 4-Ethyl-6,7-dimethoxy-9H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester hydrochloride
Purity: ≥98%
Biological Activity
DMCM hydrochloride is a benzodiazepine inverse agonist that displays anxiogenic and potent convulsant activity.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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DMCM: a potent convusive benzodiazepine receptor ligand.
Petersen
Eur.J.Pharmacol., 1983;94:117 -
Behavioral differences between subgroups of rats with high and low threshold to clonic convulsions induced by DMCM, a benzodiazepine inverse agonist.
Conto et al.
Pharmacol.Biochem.Behav., 2005;82:417
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Citations for DMCM hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for DMCM hydrochloride include:
3 Citations: Showing 1 - 3
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Reducing GABAA-mediated inhibition improves forelimb motor function after focal cortical stroke in mice
Authors: Alia Et al.
Scientific Reports 2016;6:37823
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Synaptic GABAA receptor clustering without the γ2 subunit.
Authors: Kerti-Szigeti Et al.
J Virol 2014;34:10219
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GABA(A) receptors implicated in REM sleep control express a benzodiazepine binding site.
Authors: Nguyen Et al.
J Neurosci 2013;1527:131
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